Lakes help increase the sustainability of the natural environment and decrease food chain risk, agriculture, ecosystem services, and leisure recreational activities locally and globally. Reliable simulation of monthly lake water levels is still an ongoing demand for multiple environmental and hydro-informatics engineering applications. The current research aims to utilize newly developed hybrid data-intelligence models based on the ensemble adaptive neuro-fuzzy inference system (ANFIS) coupled with metaheuristics algorithms for lake water-level simulation by considering the effect of seasonality on Titicaca Lake water-level fluctuations. The classical ANFIS model was trained using three metaheuristics nature-inspired optimization algorithms, including the genetic algorithm (ANFIS-GA), particle swarm optimizer (ANFIS-PSO), and whale optimization algorithm (ANFIS-WOA).