The thermal shock resistance of the 4D-inplane carbon/carbon composite has been predicted using the simulations of the laser irradiation test. Firstly, the effective homogenized temperature dependent properties of the carbon/carbon (c/c) composite have been predicted using realistic unit cell. The meso-scale unit cell has been reconstructed using the reconstructed images of the composite obtained through X-Ray computed tomography. The meso unit cell includes the realistic microstructural features such as fiber bundle distortions and irregular shaped big voids in the geometry. The bundles of the reconstructed unit cell are further considered as a unidirectional composite and micro unit cells are utilized to define their effective behavior. Two-scale asymptotic expansion homogenization method has been used along with finite element method and periodic boundary conditions for the prediction of effective properties. Later, thermo-mechanical transient two-dimensional analysis of a cylindrical specimen has been conducted. The irradiation laser beam parameters e.g. diameters of beam and heat flux have been varied to study the critical values of laser power density (LPD). The maximum shear strength failure criterion is used to define the ultimate state. The obtained trend of the variation of LPD is validated using the data available in the literature for 2D C/C composites. It has been observed that the present results are in good agreement with those existing in the literature. The thermal shock resistant capability of 4DIN C/C composite is found around 10–18 times higher than that of 2D C/C composite.