Mizoram (India) is part of UNESCO’s biodiversity hotspots in India that is primarily populated by tribes who engage in shifting agriculture. Hence, the land use land cover (LULC) pattern of the state is frequently changing. We have used Landsat 5 and 8 satellite images to prepare LULC maps from 2000 to 2020 in every 5 years. The atmospherically corrected images were pre-processed for removal of cloud cover and then classified into six classes: waterbodies, farmland, settlement, open forest, dense forest, and bare land. We applied four machine learning (ML) algorithms for classification, namely, random forest (RF), classification and regression tree (CART), minimum distance (MD), and support vector machine (SVM) for the images from 2000 to 2020. With 80% training and 20% testing data, we found that the RF classifier works best with the most accuracy than other classifiers. The average overall accuracy (OA) and Kappa coefficient (KC) from 2000 to 2020 were 84.00% and 0.79 when the RF classifier was used. When using SVM, CART, and MD, the average OA and KC were 78.06%, 0.73; 78.60%, 0.72; and 73.32%, 0.65, respectively. We utilised three methods of topographic correction, namely, C-correction, SCS (sun canopy sensor) correction, and SCS + C correction to reduce the misclassification due to shadow effects. SCS + C correction worked best for this region; hence, we prepared LULC maps on SCS + C corrected satellite image. Hence, we have used RF classifier for LULC preparation demi-decadal from 2000 to 2020. The OA for 2000, 2005, 2010, 2015, and 2020 was found to be 84%, 81%, 81%, 85%, and 89%, respectively, using RF. The dense forest decreased from 2000 to 2020 with an increase in open forest, settlement, and agriculture; nevertheless, when Farmland was low, there was an increase in the barren land. The results were significantly improved with the topographic correction, and misclassification was quite less.