This study is an attempt to determine the spatial-temporal pattern of meteorological droughts and exploration of the relationship between drought and elevation over Indus River basin. Gridded monthly precipitation and temperature data of 0.12°×0.12° spatial resolution for a time period of 42 years (1979–2020) is utilized. Modified Mann-Kendall test and Sen’s slope method have been used to identify significant trends in the region. Drought events are identified based on Standardized Precipitation Evapotranspiration Index (SPEI) by determining of SPEI-annual and SPEI-seasonal (pre-monsoon, monsoon, post-monsoon, and winter). Results show that the trends in the drought indices have very high heterogeneity across different seasons. Overall, 13% (14%) stations show drying (wetting) trends for annual time series analysis. However, seasonally, it is found that monsoon and post- monsoon seasons have larger area in the basin with wetting trends. Moreover, pre-monsoon season have larger area with drying trends. A correlation between SPEI trends with respect to elevation is observed.