Monitoring of radioactivity in an environment is an important step towards establishing the baseline for environment protection. This work highlights the spatial distribution of uranium (U); assessment of physico-chemical parameters and radiological assessment in groundwater of Hamirpur district, HP, India. The concentration of U ranges from 0.15 to 18.92 μg l⁻¹. High correlation of U is observed with TDS, Chloride and Nitrate. Major concentration of U is present along the NW–SE trend-line following the Siwalik in the areas where mineralisation is prevalent and is of geogenic source derived from granitic and volcanic rock fragments present in conglomerates. The water-quality-index indicates that the water is suitable for drinking purpose.